Biohazard Games (but published by Fantasy Flight Games). It's a fairly hard, near-future science fiction game based on the colony world of Poseidon. Poseidon is about 98% water-covered (hence the name). The setting is detailed and tries hard to be 'realistic.' Difficult political and ethical choices are writ large in the background. The technology level is more biopunk than cyberpunk, with many people having (minor) genetic modifications.
We've played two campaigns of Blue Planet.
Another was Red Sky Charters, a game of freelance gophers based in Harmony.